Science Inventory

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Presentation to Duke University, Toxicology & Environmental Health Seminar

This sub-product is a journal article that compares a variety of computational approaches for calculating transcriptomic points of departure (tPODs) from in vitro high-throughput transcriptomics (HTTr) screening data.  The manuscript uses a data set of 44 chemicals tested in...

Per- and polyfluoroalkyl substances (PFAS) have emerged as high priority contaminants due to their ubiquity and pervasiveness in the environment. Numerous PFAS co-occur across sources of drinking water, including areas of North Carolina (NC) with some detected concentrations abov...

Presentation to Michigan State University Institute for Integrative Toxicology Search for CCTE records in EPA’s Science Inventory by typing in the title at this link.https://cfpub.epa.gov/si/si_public_search_results.cfm?advSearch=true&showCriteria=2&keyword=CCTE&amp...

High throughput toxicokinetics (HTTK) has brought a suite of models for translating new approach method (NAM) datasets to appropriate dose contexts for comparison to exposure estimates and traditional data types to foster scientific confidence and acceptance of NAMs. One importan...

Presentation to the University of North Carolina at Chapel Hill ENVR 500 class: Environmental Processes, Exposure, and Risk Assessment March 2024

Regulatory organizations such as the U.S. Environmental Protection Agency (EPA) assess the potential environmental persistence of manufactured chemicals based on their physicochemical properties and transformation rates. Hydrolytic degradation is an important environmental transf...

Dermal uptake is an important and complex exposure route for a wide range of chemicals. Dermal exposure can occur due to occupational settings, pharmaceutical applications, environmental contamination, or consumer product use. The large range of both chemicals and scenarios of in...

Pesticides, pharmaceuticals, and other organic contaminants often undergo hydrolysis when released into the environment; therefore, measured or estimated hydrolysis rates are needed to assess their environmental persistence. An intuitive multiple linear regression (MLR) approach ...

This product will investigate how HTTK, with appropriately propagated uncertainty, enhances new approach methodology (NAM)-based prediction of in vivo points of departure to inform regulatory decision making. Since 2017 a series of Accelerating the Pace of Chemical Risk Assessmen...

The purpose of this presentation is to demonstrate how work under the APCRA and in EPA-ORD-CCTE has advanced our understanding of the utility of new approach methods-based points-of-departure (POD-NAMs).

‘Cell Painting’ is an imaging-based high-throughput phenotypic profiling (HTPP) method in which cultured cells are fluorescently labeled to visualize subcellular structures (i.e., nucleus, nucleoli, endoplasmic reticulum, cytoskeleton, Golgi apparatus / plasma me...

Hydrolytic degradation is an important mechanism in aquatic environments. Many of the manufactured chemicals introduced to aquatic environments are organic pollutants (including polymers, plasticizers, etc) that hydrolyze at OC=O functional groups/substructures. To prioritize and...

Human health risk assessment often evaluates multiple endpoint variables in order to form a comprehensive picture of the toxicity effects of an environmental chemical or toxicant. Benchmark dose (BMD) modeling is a flexible method that takes the shape of ...

Presentation to the Biosolids Science Advisory Board (SAB) Meeting May 2023. Biosolids, or treated sewage sludge, are produced from wastewater treatment processes and can be beneficially used or disposed. Section 405(d) of the Clean Water Act (CWA) requires EPA to review sewage s...

In vitro approaches for identifying hepatotoxicity hazard have the potential to accelerate or augment chemical risk assessment and contribute to reductions in the use of animals for toxicity testing. High-content imaging (HCI) assays have been applied to rodent and human-derived ...

Traditionally, risk assessment for environmental chemicals is based upon epidemiological and/or animal toxicity data. Since the release of the National Academy of Sciences Toxicity in the 21st Century: A Vision and a Strategy (2007) and Science and Decisions: Advancing Risk Asses...

The landscape of chemical risk assessment has been evolving with recent advancements in biomedical and computational sciences, as best represented respectively by biomarker discovery and physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling.  The integration of...

The US EPA is obtaining scientific peer-review and public comment on a new draft ORD human health assessment product for data poor chemicals and a case study evaluating the human health and economic trade-offs of the draft assessment product. This will be done in two meetings, th...

Presentation to the Organization for Economic Co-operation and Development (OECD) Working Party for Hazard Assessment Update Meeting June 2023. The US EPA is obtaining scientific peer-review and public comment on a new draft ORD human health assessment product for data poor chemi...

The US EPA is obtaining scientific peer-review and public comment on a new draft ORD human health assessment product for data poor chemicals and a case study evaluating the human health and economic trade-offs of the draft assessment product. This will be done in two meetings, th...

The US EPA is obtaining scientific peer-review and public comment on a new draft human health assessment product for data poor chemicals and a case study evaluating the human health and economic trade-offs of the draft assessment product. Three EPA reports are being developed for...

Toxicology has been an active research field for many decades, with academic, industrial and government involvement. Modern omics and computational approaches are changing the field, from merely disease-specific observational models into target-specific predictive models. Traditi...

Start with the EPA’s CompTox Chemicals Dashboard to discover toxicological data and resources for over 900,000 chemicals. The Dashboard connects a wealth of chemistry, in vivo (human health and ecotoxicology relevant), in vitro, and exposure and functional-use database...

The EPA Transcriptomic Assessment Product (ETAP) is a proposed ORD assessment product that utilizes a standardized short-term in vivo study design and data analysis procedures to develop transcriptomic-based reference values for data poor chemicals. The goal is to develop and ope...